Can Increasing Dopamine In The Prefrontal Cortex Do Opposite Things?

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Can increasing dopamine in the prefrontal cortex do opposite things for brains with high D2/D1 receptor ratio, as compared with brains with low D2/D1 receptor ratio?

You might want to look up Sumanirole - Wikipedia which was the only selective D2 dopamine receptor agonist I am aware of, and it was never approved for medical use, it was mainly a research tool. UH-232 - Wikipedia was developed to treat schizophrenia, but actually made symptoms worse in clinical trials which were discontinued. I have used partial D2 dopamine receptor agonists including LSD, ketamine and Aripiprazole - Wikipedia (Abilify) All of those have extremely different effects, and, especially in the case of LSD, have quite variable effects, even in the same person under similar conditions. I doubt you will find anyone who can answer your question, and if you could find more than one, you might get very different responses from each.

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